ABSTRACT
Objective:To investigate the correlation between methylenetetrahydrofolate reductase (MTHFR) gene polymorphism and early neurological deterioration (END) in Han population with acute ischemic stroke in Chengdu area, and the interaction with other traditional risk factors.Methods:Consecutive Han patients with acute ischemic stroke admitted to the Department of Neurology, the Third People's Hospital of Chengdu from January 2017 to June 2019 were enrolled prospectively. Using the candidate gene association study method, MTHFR gene C677T polymorphism was used as a genetic marker to analyze the correlation between END and MTHFR gene polymorphism, and analyze the interaction of gene-END traditional risk factors.Results:A total of 434 patients with acute ischemic stroke were enrolled in the study, and 129 had END (29.7%). Multivariate logistic regression analysis showed that hyperglycemia (odds ratio [ OR] 2.410, 95% confidence interval [ CI] 1.436-4.046; P<0.001), hyperhomocysteinemia ( OR 2.570, 95% CI 1.229-5.376; P=0.012) and moderate to severe neurological deficit (baseline National Institutes of Health Stroke Scale score >5) ( OR 2.158, 95% CI 1.337-3.484; P=0.002) at admission were independently correlated with END. There was a correlation between C677T polymorphism and END. TT genotype ( OR 1.710, 95% CI 1.021-2.863; P=0.002) and A allele ( OR 1.583, 95% CI 1.181-2.121; P=0.002) could significantly increase the risk of END. Interaction analysis showed that there was interaction effect between C677T polymorphism and hyperglycemia at admission, alcohol drinking and moderate to severe neurological deficit. Interaction could increase the risk of END, but it did not reach statistical significance ( OR 1.237, 95% CI 0.227-6.734; P=0.806). Conclusion:MTHFR gene C677T polymorphism and hyperhomocysteinemia are associated with END in Han population with acute ischemic stroke in Chengdu area.
ABSTRACT
ObjectiveTo investigate the prevalence o f erectile dysfuction (ED) in Beijing urban ared,and to study the influence of dem ographic and other risk factors.MethodsUsing systemic epidemiological method, 1247 married men in Beijing urban area were selected by two-stage sample methods.General condition, health status, medications, smok ing and lifestyle was collected by trained interviewers.A self-administered sex ual activity questionnaire (IIEF-5) was used to characterize erectile potency. ResultsThe prevalence rate of ED of married men in Bei jing is 39.1%,and the prevalence rate of ED over 40 years is 54.5%.ED was strong ly correlated with age,especially for men over 60 years.The prevalence rate of c omplete ED in 60～69 years group is nearly 5 times as in 50～59 years group.The ot her important factors correlated with ED include diabetes,vascular disease and s o on.ConclusionsThe prevalence of ED in Beijing urban area and the important risk factors are similar to those reported.Whereas the pr evalence rate of complete ED over 60 years is significantly higher.